67814-76-0 Isepamicin sulfate AKSci J51503
 
 
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  J51503    
Isepamicin sulfate, 95%
 



IDENTITY
CAS Number:67814-76-0
MDL Number:MFCD01683537
MF:C22H43N5O12.H2S04
MW:667.68
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:235-242°C
Optical Rotation:+110.9° (c=1, H2O as the disulfate hydrate)
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Form:Sulfate salt

REVIEW
 Isepamicin (also known as isepamycin) is an aminoglycoside antibacterial with good activity against strains producing type I 6''-acetyltransferase, a upregulated enzyme present in resistant strains. The antibacterial spectrum includes Enterobacteriaceae and staphylococci. Anaerobes, Neisseriaceae and streptococci are resistant. Recent work has also indicated that isepamicin might be active in vitro against Gram-negative bacteria with resistance to amikacin and other aminoglycosides.

REFERENCES
[1]Miller, George H.; Chiu, Peter J. S.; Waitz, J. Allan Biological activity of Sch 21420, the 1-N-S-alpha-hydroxy-beta-aminopropionyl derivative of gentamicin B Journal of Antibiotics (1978), 31(7), 688-96.
[2] Sanders, Christine C.; Sanders, W. Eugene, Jr.; Goering, Richard V In vitro studies with Sch 21420 and Sch 22591: activity in comparison with six other aminoglycosides and synergy with penicillin against enterococci Antimicrobial Agents and Chemotherapy (1978), 14(2), 178-84.
[3] Bruss, Jon B.; Kostrub, Corwin F.; Armstrong, Eliana Saxon; Cass, Robert T.; Miller, George H.; Aggen, James Bradley; Goldblum, Adam Aaron; Dozzo, Paola; Linsell, Martin Sheringham Preparation of aminoglycosides as antibacterial agents PCT Int. Appl. (2010), WO 2010132839 A2 20101118.
[4] Falagas ME, Karageorgopoulos DE, Georgantzi GG, Sun C, Wang R, Rafailidis PI Susceptibility of Gram-negative bacteria to isepamicin: a systematic review. Expert Rev Anti Infect Ther. 2012 Feb;10(2):207-18.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of June 12, 2024


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CATEGORIES
 APIs and Bioactives > Antibacterials, Aminoglycosides


PubChem
  @PubMed